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Dasanix 100mg Tablet 10pcs
Dasanix (Dasatinib), which is primarily used for the treatment of Philadelphia chromosome-positive (Ph+) leukemia.
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✅ Description:
Dasatinib works by inhibiting multiple kinases (e.g., BCR-ABL, SRC family kinases) and can overcome resistance to prior treatments like Imatinib. Key properties include:
- Absorption: Peaks in 0.5 to 6 hours.
- Distribution: Binds ~96% to plasma proteins.
- Metabolism: Primarily metabolized by CYP3A4.
- Excretion: Mostly via feces (~85%).
- Treatment of adult patients with:
- Newly diagnosed Ph+ CML in the chronic phase.
- Advanced phases of CML or Ph+ ALL with resistance or intolerance to prior therapy.
- Treatment of pediatric patients (1 year and older) with:
- Chronic phase Ph+ CML.
- Newly diagnosed Ph+ ALL (in combination with chemotherapy).
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Blood cancer (Chronic myeloid leukemia)
✔️ How does
Dasatinib works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
✔️ Dosage and Administration
Adults:
- Chronic phase CML: 100 mg orally once daily.
- Advanced phases of CML/Ph+ ALL: 140 mg orally once daily.
- Tablets must be swallowed whole, not crushed or cut.
Pediatrics:
- Dosage is based on body weight, ranging from 40 mg to 100 mg daily.
- Regular recalculation of doses based on weight changes is necessary.
✔️ Common adverse reactions include:
- Myelosuppression
- Bleeding events
- Fluid retention
- Pulmonary arterial hypertension
- QT prolongation
- Severe dermatologic reactions
✔️ Interactions
- CYP3A4 inhibitors/inducers: May increase or decrease Dasanix levels, affecting efficacy and toxicity.
- Gastric acid-reducing agents: Avoid proton pump inhibitors and H2 antagonists; use antacids instead with proper timing.
✔️ Pregnancy and Lactation
- Contraindicated in pregnancy due to potential fetal harm.
- Breastfeeding is not recommended during and up to 2 weeks after the last dose.
✔️ Precautions and Warnings
- Myelosuppression: Requires frequent blood count monitoring.
- Fluid retention and cardiovascular events: Monitor and manage as needed.
- Pulmonary arterial hypertension (PAH): Evaluate for cardiopulmonary issues before and during treatment.
- QT prolongation: Monitor patients with risk factors.
- Severe dermatologic reactions: Discontinue if severe mucocutaneous reactions occur.
- Tumor lysis syndrome: Ensure proper hydration and monitoring in high-risk patients.
✔️ Storage
- Store below 30°C in a dry, light-protected place.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
